Excisional Biopsy Report

THE JOHNS HOPKINS HOSPITAL

SURGICAL PATHOLOGY

401 N. Broadway  

Baltimore, Md 21231-2410    

JHH MR #

Accessioned 09/13/2012

Birthdate:  

Loc: ORHLO

Gender: M            

Spec. Taken 09/13/2012

JHH Physician: WAYNE MARTIN KOCH, M.D.

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INTERPRETATION AND DIAGNOSIS:  (mxv)   09/20/2012 @ 01:54 pm

LEFT NECK MASS (EXCISION): CLASSICAL HODGKIN LYMPHOMA, MIXED

CELLULARITY TYPE.  SEE NOTE.

NOTE:  The specimen contains sections of lymph node.  The

architecture is effaced by a diffuse inflammatory infiltrate

containing prominent clusters of epithelioid histiocytes and

lymphocytes.  There are scattered Reed-Sternberg and variant cells as

well as mummified cells present within the lymph node.

A panel of immunostains performed at JHH (CD20, CD3, CD30, CD15, and

Pax-5) and in situ hybridization for EBV (EBER) was reviewed.  The

background lymphocytes contain a mixture of CD20 positive B-cells and

CD3-positive T-cells, with T-lymphocytes predominating.  The

Reed-Sternberg and Hodgkin cells show a strong membrane staining for

CD30 and CD15, and a weak nuclear staining for Pax-5.   An in situ

hybridization for EBV-encoded RNA (EBER) is negative.

The findings are consistent with classical Hodgkin lymphoma, mixed

cellularity type.

*Electronic signature (09/20/2012 @ 01:54 pm) by which I attest that

the above diagnosis is based upon my personal examination of the

slides (and / or other material indicated in the diagnosis), and

that I have reviewed and approved this report.

Some stains/tests used in arriving at the diagnosis were performed

here using reagents that have not been cleared or approved by the

US Food and Drug Administration.  These were developed and their

performance characteristics determined by the Johns Hopkins Medical

Laboratories.  Their use does not require FDA approval.

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GROSS DESCRIPTION

PART #1: LEFT NECK LYMPH NODE  (fas)

Resident Pathologist:   09/13/2012

Dictated by

The specimen is received fresh, labeled Lastname, Firstname and is

designated as left neck lymph node.  The specimen consists of one

piece of pale tan soft tissue, measuring 2.1 x 1.1 x 1.1 cm.  The

specimen is bisected and submitted in its entirety.

SUMMARY OF SECTIONS:

1 - A - 2

1 - TOTAL - 2

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